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KMID : 1007520130220030839
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Food Science and Biotechnology
2013 Volume.22 No. 3 p.839 ~ p.844
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Antioxidation and Antiglycation of 95% Ethanolic Extracts Prepared from the Leaves of Black Nightshade (Solanum nigrum)
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Hou Tsung-Han
Chung Jen-Ping
Chen Shang-Shan
Chang Tsu-Liang
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Abstract
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Hyperglycemia results in the formation of advanced glycation end-products (AGE), resulting in an inflammatory response that induces insulin resistance. Evidence indicates that antioxidants can suppress the formation of reactive oxygen species, decrease levels of AGEs by inhibiting glycation. Black nightshade (Solanum nigrum) can be used as a medicinal food for improving blood glucose; however, the identities of the active compounds and how they counteract diabetes remain unknown. This study demonstrate that 95% ethanolic extracts of black nightshade exerted significant antioxidative activity compared with 50% ethanolic extracts and aqueous extracts. Moreover, 95% ethanolic extracts of black nightshade produced antiglycative activity, which contributed to the inhibition of fructosamine and generation of α-dicarbonyl compounds. The concentrations of solasonine and solamargine in the 95% ethanolic extracts were 0.484 and 0.183 mg/mg, respectively. These results suggest that black nightshade might serve as a novel source of functional ingredients that exert antiglycation and anti-diabetes activities.
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KEYWORD
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advanced glycation end-product (AGE), antioxidative activity, Solanum nigrum, antiglycation, antidiabetes
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